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The Role of Genomic Data in the Discovery, Annotation and Evolutionary Interpretation of the Interferon-Lambda Family

BACKGROUND: Type-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone. We have previously described the discovery of the human type-III interfe...

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Detalles Bibliográficos
Autores principales: Fox, Brian A., Sheppard, Paul O., O'Hara, Patrick J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654155/
https://www.ncbi.nlm.nih.gov/pubmed/19300512
http://dx.doi.org/10.1371/journal.pone.0004933