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Genome-Wide Hypomethylation in Head and Neck Cancer Is More Pronounced in HPV-Negative Tumors and Is Associated with Genomic Instability

Loss of genome-wide methylation is a common feature of cancer, and the degree of hypomethylation has been correlated with genomic instability. Global methylation of repetitive elements possibly arose as a defense mechanism against parasitic DNA elements, including retrotransposons and viral pathogen...

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Detalles Bibliográficos
Autores principales:	Richards, Kristy L., Zhang, Baili, Baggerly, Keith A., Colella, Stefano, Lang, James C., Schuller, David E., Krahe, Ralf
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654169/ https://www.ncbi.nlm.nih.gov/pubmed/19293934 http://dx.doi.org/10.1371/journal.pone.0004941

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