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Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity

BACKGROUND: Melanin synthesis, the elective trait of melanocytes, is regulated by tyrosinase activity. In tyrosinase-positive amelanotic melanomas this rate limiting enzyme is inactive because of acidic endo-melanosomal pH. The E5 oncogene of the Human Papillomavirus Type 16 is a small transmembrane...

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Detalles Bibliográficos
Autores principales:	Di Domenico, Fabio, Foppoli, Cesira, Blarzino, Carla, Perluigi, Marzia, Paolini, Francesca, Morici, Salvatrice, Coccia, Raffaella, Cini, Chiara, De Marco, Federico
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654431/ https://www.ncbi.nlm.nih.gov/pubmed/19133143 http://dx.doi.org/10.1186/1756-9966-28-4

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