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Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People

The urinary concentrations of 8-isoprostane and 8-hydroxy-2’-deoxyguanosine (8-OHdG), which are biomarkers of oxidative stress, were measured in 677 Japanese people without any diseases, and their correlations with lifestyle facotrs, lifestyle-related blood biochemical parameters, and dietary intake...

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Autores principales: Sakano, Noriko, Wang, Da-Hong, Takahashi, Noriko, Wang, Bingling, Sauriasari, Rani, Kanbara, Sakiko, Sato, Yoshie, Takigawa, Tomoko, Takaki, Jiro, Ogino, Keiki
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654475/
https://www.ncbi.nlm.nih.gov/pubmed/19308273
http://dx.doi.org/10.3164/jcbn.08-252
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author Sakano, Noriko
Wang, Da-Hong
Takahashi, Noriko
Wang, Bingling
Sauriasari, Rani
Kanbara, Sakiko
Sato, Yoshie
Takigawa, Tomoko
Takaki, Jiro
Ogino, Keiki
author_facet Sakano, Noriko
Wang, Da-Hong
Takahashi, Noriko
Wang, Bingling
Sauriasari, Rani
Kanbara, Sakiko
Sato, Yoshie
Takigawa, Tomoko
Takaki, Jiro
Ogino, Keiki
author_sort Sakano, Noriko
collection PubMed
description The urinary concentrations of 8-isoprostane and 8-hydroxy-2’-deoxyguanosine (8-OHdG), which are biomarkers of oxidative stress, were measured in 677 Japanese people without any diseases, and their correlations with lifestyle facotrs, lifestyle-related blood biochemical parameters, and dietary intake of antioxidative vitamins were investigated. The mean urinary concentration of 8-isoprostane and 8-OHdG was 0.58 ng/mg creatinine and 8.43 ng/mg creatinine, respectively. Mean urinary 8-isoprostane was significantly different in terms of age, gender, smoking and alcohol consumption but not different in terms of body mass index (BMI) and exercise. By multiple regression analysis, urinary 8-isoprostane was significantly influenced by smoking and age. On the other hand, mean urinary 8-OHdG showed differences only by age group. Multiple regression analysis revealed that urinary 8-OHdG was significantly influenced by age, smoking, body weight, levels of high-sensitivity C-reactive protein (Hs-CRP) and low density lipoprotein-cholesterol in females, although it was significantly influenced by body weight in males. The present study shows that urinary 8-isoprostane is associated with lipid peroxidation related-lifestyles such as smoking, and urinary 8-OHdG is associated with arteriosclerosis related-factors such as Hs-CRP. Our findings suggest that 8-isoprostane and 8-OHdG appear to be prospective biomarkers for early prediction of lifestyle related-disease risk at the population level.
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spelling pubmed-26544752009-03-23 Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People Sakano, Noriko Wang, Da-Hong Takahashi, Noriko Wang, Bingling Sauriasari, Rani Kanbara, Sakiko Sato, Yoshie Takigawa, Tomoko Takaki, Jiro Ogino, Keiki J Clin Biochem Nutr Original Article The urinary concentrations of 8-isoprostane and 8-hydroxy-2’-deoxyguanosine (8-OHdG), which are biomarkers of oxidative stress, were measured in 677 Japanese people without any diseases, and their correlations with lifestyle facotrs, lifestyle-related blood biochemical parameters, and dietary intake of antioxidative vitamins were investigated. The mean urinary concentration of 8-isoprostane and 8-OHdG was 0.58 ng/mg creatinine and 8.43 ng/mg creatinine, respectively. Mean urinary 8-isoprostane was significantly different in terms of age, gender, smoking and alcohol consumption but not different in terms of body mass index (BMI) and exercise. By multiple regression analysis, urinary 8-isoprostane was significantly influenced by smoking and age. On the other hand, mean urinary 8-OHdG showed differences only by age group. Multiple regression analysis revealed that urinary 8-OHdG was significantly influenced by age, smoking, body weight, levels of high-sensitivity C-reactive protein (Hs-CRP) and low density lipoprotein-cholesterol in females, although it was significantly influenced by body weight in males. The present study shows that urinary 8-isoprostane is associated with lipid peroxidation related-lifestyles such as smoking, and urinary 8-OHdG is associated with arteriosclerosis related-factors such as Hs-CRP. Our findings suggest that 8-isoprostane and 8-OHdG appear to be prospective biomarkers for early prediction of lifestyle related-disease risk at the population level. the Society for Free Radical Research Japan 2009-03 2009-02-28 /pmc/articles/PMC2654475/ /pubmed/19308273 http://dx.doi.org/10.3164/jcbn.08-252 Text en Copyright © 2009 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sakano, Noriko
Wang, Da-Hong
Takahashi, Noriko
Wang, Bingling
Sauriasari, Rani
Kanbara, Sakiko
Sato, Yoshie
Takigawa, Tomoko
Takaki, Jiro
Ogino, Keiki
Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People
title Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People
title_full Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People
title_fullStr Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People
title_full_unstemmed Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People
title_short Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People
title_sort oxidative stress biomarkers and lifestyles in japanese healthy people
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654475/
https://www.ncbi.nlm.nih.gov/pubmed/19308273
http://dx.doi.org/10.3164/jcbn.08-252
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