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Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections
The genetic make-up of the host has a major influence on its response to combat pathogens. For influenza A virus, several single gene mutations have been described which contribute to survival, the immune response and clearance of the pathogen by the host organism. Here, we have studied the influenc...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654507/ https://www.ncbi.nlm.nih.gov/pubmed/19293935 http://dx.doi.org/10.1371/journal.pone.0004857 |
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author | Srivastava, Barkha Błażejewska, Paulina Heßmann, Manuela Bruder, Dunja Geffers, Robert Mauel, Susanne Gruber, Achim D. Schughart, Klaus |
author_facet | Srivastava, Barkha Błażejewska, Paulina Heßmann, Manuela Bruder, Dunja Geffers, Robert Mauel, Susanne Gruber, Achim D. Schughart, Klaus |
author_sort | Srivastava, Barkha |
collection | PubMed |
description | The genetic make-up of the host has a major influence on its response to combat pathogens. For influenza A virus, several single gene mutations have been described which contribute to survival, the immune response and clearance of the pathogen by the host organism. Here, we have studied the influence of the genetic background to influenza A H1N1 (PR8) and H7N7 (SC35M) viruses. The seven inbred laboratory strains of mice analyzed exhibited different weight loss kinetics and survival rates after infection with PR8. Two strains in particular, DBA/2J and A/J, showed very high susceptibility to viral infections compared to all other strains. The LD(50) to the influenza virus PR8 in DBA/2J mice was more than 1000-fold lower than in C57BL/6J mice. High susceptibility in DBA/2J mice was also observed after infection with influenza strain SC35M. In addition, infected DBA/2J mice showed a higher viral load in their lungs, elevated expression of cytokines and chemokines, and a more severe and extended lung pathology compared to infected C57BL/6J mice. These findings indicate a major contribution of the genetic background of the host to influenza A virus infections. The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses. |
format | Text |
id | pubmed-2654507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-26545072009-03-18 Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections Srivastava, Barkha Błażejewska, Paulina Heßmann, Manuela Bruder, Dunja Geffers, Robert Mauel, Susanne Gruber, Achim D. Schughart, Klaus PLoS One Research Article The genetic make-up of the host has a major influence on its response to combat pathogens. For influenza A virus, several single gene mutations have been described which contribute to survival, the immune response and clearance of the pathogen by the host organism. Here, we have studied the influence of the genetic background to influenza A H1N1 (PR8) and H7N7 (SC35M) viruses. The seven inbred laboratory strains of mice analyzed exhibited different weight loss kinetics and survival rates after infection with PR8. Two strains in particular, DBA/2J and A/J, showed very high susceptibility to viral infections compared to all other strains. The LD(50) to the influenza virus PR8 in DBA/2J mice was more than 1000-fold lower than in C57BL/6J mice. High susceptibility in DBA/2J mice was also observed after infection with influenza strain SC35M. In addition, infected DBA/2J mice showed a higher viral load in their lungs, elevated expression of cytokines and chemokines, and a more severe and extended lung pathology compared to infected C57BL/6J mice. These findings indicate a major contribution of the genetic background of the host to influenza A virus infections. The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses. Public Library of Science 2009-03-18 /pmc/articles/PMC2654507/ /pubmed/19293935 http://dx.doi.org/10.1371/journal.pone.0004857 Text en Srivastava et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Srivastava, Barkha Błażejewska, Paulina Heßmann, Manuela Bruder, Dunja Geffers, Robert Mauel, Susanne Gruber, Achim D. Schughart, Klaus Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections |
title | Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections |
title_full | Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections |
title_fullStr | Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections |
title_full_unstemmed | Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections |
title_short | Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections |
title_sort | host genetic background strongly influences the response to influenza a virus infections |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654507/ https://www.ncbi.nlm.nih.gov/pubmed/19293935 http://dx.doi.org/10.1371/journal.pone.0004857 |
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