Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

BACKGROUND: Palmitate is a potent inducer of endoplasmic reticulum (ER) stress in β-cells. In type 2 diabetes, glucose amplifies fatty-acid toxicity for pancreatic β-cells, leading to β-cell dysfunction and death. Why glucose exacerbates β-cell lipotoxicity is largely unknown. Glucose stimulates mTO...

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Detalles Bibliográficos
Autores principales: Bachar, Etti, Ariav, Yafa, Ketzinel-Gilad, Mali, Cerasi, Erol, Kaiser, Nurit, Leibowitz, Gil
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654723/
https://www.ncbi.nlm.nih.gov/pubmed/19305497
http://dx.doi.org/10.1371/journal.pone.0004954

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