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Gene network reconstruction from transcriptional dynamics under kinetic model uncertainty: a case for the second derivative

Motivation: Measurements of gene expression over time enable the reconstruction of transcriptional networks. However, Bayesian networks and many other current reconstruction methods rely on assumptions that conflict with the differential equations that describe transcriptional kinetics. Practical ap...

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Detalles Bibliográficos
Autores principales: Bickel, David R., Montazeri, Zahra, Hsieh, Pei-Chun, Beatty, Mary, Lawit, Shai J., Bate, Nicholas J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654806/
https://www.ncbi.nlm.nih.gov/pubmed/19218351
http://dx.doi.org/10.1093/bioinformatics/btp028