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Gene network reconstruction from transcriptional dynamics under kinetic model uncertainty: a case for the second derivative
Motivation: Measurements of gene expression over time enable the reconstruction of transcriptional networks. However, Bayesian networks and many other current reconstruction methods rely on assumptions that conflict with the differential equations that describe transcriptional kinetics. Practical ap...
Autores principales: | Bickel, David R., Montazeri, Zahra, Hsieh, Pei-Chun, Beatty, Mary, Lawit, Shai J., Bate, Nicholas J. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654806/ https://www.ncbi.nlm.nih.gov/pubmed/19218351 http://dx.doi.org/10.1093/bioinformatics/btp028 |
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