Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process

A key process in the lifecycle of the malaria parasite Plasmodium falciparum is the fast invasion of human erythrocytes. Entry into the host cell requires the apical membrane antigen 1 (AMA-1), a type I transmembrane protein located in the micronemes of the merozoite. Although AMA-1 is evolving into...

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Detalles Bibliográficos
Autores principales: Treeck, Moritz, Zacherl, Sonja, Herrmann, Susann, Cabrera, Ana, Kono, Maya, Struck, Nicole S., Engelberg, Klemens, Haase, Silvia, Frischknecht, Friedrich, Miura, Kota, Spielmann, Tobias, Gilberger, Tim W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654807/
https://www.ncbi.nlm.nih.gov/pubmed/19283086
http://dx.doi.org/10.1371/journal.ppat.1000322

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