Cargando…
Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy
BACKGROUND: Inflammation contributes to cardiovascular complications in type 2 diabetes, which are often characterized by microvascular alterations. We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted by transmigrating monocytes and granulocytes may represent a biomarker...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654885/ https://www.ncbi.nlm.nih.gov/pubmed/19232095 http://dx.doi.org/10.1186/1475-2840-8-10 |
_version_ | 1782165414806028288 |
---|---|
author | Burkhardt, Klaus Schwarz, Sonja Pan, Chengrui Stelter, Felix Kotliar, Konstantin Von Eynatten, Maxilian Sollinger, Daniel Lanzl, Ines Heemann, Uwe Baumann, Marcus |
author_facet | Burkhardt, Klaus Schwarz, Sonja Pan, Chengrui Stelter, Felix Kotliar, Konstantin Von Eynatten, Maxilian Sollinger, Daniel Lanzl, Ines Heemann, Uwe Baumann, Marcus |
author_sort | Burkhardt, Klaus |
collection | PubMed |
description | BACKGROUND: Inflammation contributes to cardiovascular complications in type 2 diabetes, which are often characterized by microvascular alterations. We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted by transmigrating monocytes and granulocytes may represent a biomarker for microvascular alterations in patients with type 2 diabetes and nephropathy. METHODS: MRP8/14 was measured in 43 patients with type 2 diabetes and nephropathy. Additionally, the inflammatory markers Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were quantified. To detect microvascular alterations proteinuria and retinal vessel caliber were used as classical and novel marker, respectively. Proteinuria was quantified by protein-creatinine ratio (PCR); retinal vessel caliber was quantified after retina photography on digitalized retina pictures. RESULTS: MRP8/14 was positively associated with inflammation (r = 0.57), proteinuria (r = 0.40) and retinal arterial caliber (r = 0.48). Type 2 diabetic patients with MRP8/14 values above the median of 5.8 μg/ml demonstrated higher proteinuria and larger retinal artery caliber than patients with MRP8/14 values below the median (logPCR: -0.51 ± 0.52 versus -0.96 ± 0.46, P < 0.01; retinal artery lumen (μm): 178.3 ± 14.1 versus 162.7 ± 14.9 P < 0.01). Both groups did not differ with regard to metabolic factors and blood pressure. MRP8/14 was an independent predictor of retinal artery caliber in multivariate stepwise regression analysis (β = 0.607) and was positively associated with IL-6 (r = 0.57, P < 0.001) and TNF-α (r = 0.36, P < 0.05). CONCLUSION: MRP8/14 – a marker for transendothelial migration – describes not only the state of inflammation in diabetic nephropathy, but additionally the degree of microvascular alterations in the glomerular and retinal bed. Therefore, MRP8/14 may be a potentially selective novel biomarker for microcirculatory defects in diabetic nephropathy. |
format | Text |
id | pubmed-2654885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26548852009-03-13 Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy Burkhardt, Klaus Schwarz, Sonja Pan, Chengrui Stelter, Felix Kotliar, Konstantin Von Eynatten, Maxilian Sollinger, Daniel Lanzl, Ines Heemann, Uwe Baumann, Marcus Cardiovasc Diabetol Original Investigation BACKGROUND: Inflammation contributes to cardiovascular complications in type 2 diabetes, which are often characterized by microvascular alterations. We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted by transmigrating monocytes and granulocytes may represent a biomarker for microvascular alterations in patients with type 2 diabetes and nephropathy. METHODS: MRP8/14 was measured in 43 patients with type 2 diabetes and nephropathy. Additionally, the inflammatory markers Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were quantified. To detect microvascular alterations proteinuria and retinal vessel caliber were used as classical and novel marker, respectively. Proteinuria was quantified by protein-creatinine ratio (PCR); retinal vessel caliber was quantified after retina photography on digitalized retina pictures. RESULTS: MRP8/14 was positively associated with inflammation (r = 0.57), proteinuria (r = 0.40) and retinal arterial caliber (r = 0.48). Type 2 diabetic patients with MRP8/14 values above the median of 5.8 μg/ml demonstrated higher proteinuria and larger retinal artery caliber than patients with MRP8/14 values below the median (logPCR: -0.51 ± 0.52 versus -0.96 ± 0.46, P < 0.01; retinal artery lumen (μm): 178.3 ± 14.1 versus 162.7 ± 14.9 P < 0.01). Both groups did not differ with regard to metabolic factors and blood pressure. MRP8/14 was an independent predictor of retinal artery caliber in multivariate stepwise regression analysis (β = 0.607) and was positively associated with IL-6 (r = 0.57, P < 0.001) and TNF-α (r = 0.36, P < 0.05). CONCLUSION: MRP8/14 – a marker for transendothelial migration – describes not only the state of inflammation in diabetic nephropathy, but additionally the degree of microvascular alterations in the glomerular and retinal bed. Therefore, MRP8/14 may be a potentially selective novel biomarker for microcirculatory defects in diabetic nephropathy. BioMed Central 2009-02-20 /pmc/articles/PMC2654885/ /pubmed/19232095 http://dx.doi.org/10.1186/1475-2840-8-10 Text en Copyright © 2009 Burkhardt et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Investigation Burkhardt, Klaus Schwarz, Sonja Pan, Chengrui Stelter, Felix Kotliar, Konstantin Von Eynatten, Maxilian Sollinger, Daniel Lanzl, Ines Heemann, Uwe Baumann, Marcus Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy |
title | Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy |
title_full | Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy |
title_fullStr | Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy |
title_full_unstemmed | Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy |
title_short | Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy |
title_sort | myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654885/ https://www.ncbi.nlm.nih.gov/pubmed/19232095 http://dx.doi.org/10.1186/1475-2840-8-10 |
work_keys_str_mv | AT burkhardtklaus myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT schwarzsonja myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT panchengrui myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT stelterfelix myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT kotliarkonstantin myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT voneynattenmaxilian myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT sollingerdaniel myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT lanzlines myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT heemannuwe myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy AT baumannmarcus myeloidrelatedprotein814complexdescribesmicrocirculatoryalterationsinpatientswithtype2diabetesandnephropathy |