Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation

Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we have demonstrated that pharmacological lowering of glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, strikingly improves glycemic control. Here we studied the effects of AMP-DNM on adipo...

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Detalles Bibliográficos
Autores principales: van Eijk, Marco, Aten, Jan, Bijl, Nora, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Dubbelhuis, Peter F., Seeman, Ingar, Ghauharali-van der Vlugt, Karen, Overkleeft, Hermen S., Arbeeny, Cynthia, Groen, Albert K., Aerts, Johannes M. F. G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654925/
https://www.ncbi.nlm.nih.gov/pubmed/19305508
http://dx.doi.org/10.1371/journal.pone.0004723

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