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Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines

Replicon plasmids encoding an alphavirus RNA replicase constitute an alternative to conventional DNA plasmids with promise for DNA vaccination in humans. Replicase activity amplifies the levels of transgene mRNA through a copying process involving double-stranded (ds) RNA intermediates, which contri...

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Detalles Bibliográficos
Autores principales:	Diebold, Sandra S., Schulz, Oliver, Alexopoulou, Lena, Leitner, Wolfgang W., Flavell, Richard A., Reis e Sousa, Caetano
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655288/ https://www.ncbi.nlm.nih.gov/pubmed/19052633 http://dx.doi.org/10.1038/gt.2008.164

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