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Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase – ligand recognition in a template for antimicrobial drug discovery

4-Diphosphocytidyl-2C-methyl-d-erythritol kinase (IspE) catalyses the ATP-dependent conversion of 4-diphosphocytidyl-2C-methyl-d-erythritol (CDPME) to 4-diphosphocytidyl-2C-methyl-d-erythritol 2-phosphate with the release of ADP. This reaction occurs in the non-mevalonate pathway of isoprenoid precu...

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Detalles Bibliográficos
Autores principales:	Sgraja, Tanja, Alphey, Magnus S, Ghilagaber, Stephanos, Marquez, Rudi, Robertson, Murray N, Hemmings, Jennifer L, Lauw, Susan, Rohdich, Felix, Bacher, Adelbert, Eisenreich, Wolfgang, Illarionova, Victoria, Hunter, William N
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2008
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655357/ https://www.ncbi.nlm.nih.gov/pubmed/18422643 http://dx.doi.org/10.1111/j.1742-4658.2008.06418.x

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