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Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

Homing endonucleases (HEs) cut long DNA target sites with high specificity to initiate and target the lateral transfer of mobile introns or inteins. This high site specificity of HEs makes them attractive reagents for gene targeting to promote DNA modification or repair. We have generated several hu...

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Detalles Bibliográficos
Autores principales:	Li, Hui, Pellenz, Stefan, Ulge, Umut, Stoddard, Barry L., Monnat, Raymond J.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655683/ https://www.ncbi.nlm.nih.gov/pubmed/19153140 http://dx.doi.org/10.1093/nar/gkp004

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