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The effect of the TRF2 N-terminal and TRFH regions on telomeric G-quadruplex structures
The sequence of human telomeric DNA consists of tandem repeats of 5′-d(TTAGGG)-3′. This guanine-rich DNA can form G-quadruplex secondary structures which may affect telomere maintenance. A current model for telomere protection by the telomere-binding protein, TRF2, involves the formation of a t-loop...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655686/ https://www.ncbi.nlm.nih.gov/pubmed/19139067 http://dx.doi.org/10.1093/nar/gkn1081 |