Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis

A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the ‘left femur head’, which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen reveale...

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Autores principales: Yamada, Shunsuke, Taniguchi, Masatomo, Tokumoto, Masanori, Tsuruya, Kazuhiko, Iida, Mitsuo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655761/
https://www.ncbi.nlm.nih.gov/pubmed/19461864
http://dx.doi.org/10.1093/ndtplus/sfp010
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author Yamada, Shunsuke
Taniguchi, Masatomo
Tokumoto, Masanori
Tsuruya, Kazuhiko
Iida, Mitsuo
author_facet Yamada, Shunsuke
Taniguchi, Masatomo
Tokumoto, Masanori
Tsuruya, Kazuhiko
Iida, Mitsuo
author_sort Yamada, Shunsuke
collection PubMed
description A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the ‘left femur head’, which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the ‘left knee’ occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.
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spelling pubmed-26557612009-04-24 Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis Yamada, Shunsuke Taniguchi, Masatomo Tokumoto, Masanori Tsuruya, Kazuhiko Iida, Mitsuo NDT Plus Case Report A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the ‘left femur head’, which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the ‘left knee’ occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis. Oxford University Press 2009-04 2009-02-10 /pmc/articles/PMC2655761/ /pubmed/19461864 http://dx.doi.org/10.1093/ndtplus/sfp010 Text en © The Author [2009]. http://creativecommons.org/licenses/by-nc/2.0/uk/ The online version of this article has been published under an open access model http://creativecommons.org/licenses/by-nc/2.0/uk/. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org
spellingShingle Case Report
Yamada, Shunsuke
Taniguchi, Masatomo
Tokumoto, Masanori
Tsuruya, Kazuhiko
Iida, Mitsuo
Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis
title Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis
title_full Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis
title_fullStr Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis
title_full_unstemmed Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis
title_short Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis
title_sort osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655761/
https://www.ncbi.nlm.nih.gov/pubmed/19461864
http://dx.doi.org/10.1093/ndtplus/sfp010
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AT tsuruyakazuhiko osteoclastlikemultinucleatedgiantcellsinuraemictumoralcalcinosis
AT iidamitsuo osteoclastlikemultinucleatedgiantcellsinuraemictumoralcalcinosis

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