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NOD-like receptors and inflammation
The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic disease...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656221/ https://www.ncbi.nlm.nih.gov/pubmed/19090963 http://dx.doi.org/10.1186/ar2525 |
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author | Mathews, Rebeccah J Sprakes, Michael B McDermott, Michael F |
author_facet | Mathews, Rebeccah J Sprakes, Michael B McDermott, Michael F |
author_sort | Mathews, Rebeccah J |
collection | PubMed |
description | The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic diseases, as well as some more common polygenic conditions. Bacterial wall constituents and other cellular stressor molecules are recognized by a range of NLRs, which leads to activation of the innate immune response and upregulation of key proinflammatory pathways, such as IL-1β production and translocation of nuclear factor-κB to the nucleus. These signalling pathways are increasingly being targeted as potential sites for new therapies. This review discusses the role played by NLRs in a variety of inflammatory diseases and describes the remarkable success to date of these therapeutic agents in treating some of the disorders associated with aberrant NLR function. |
format | Text |
id | pubmed-2656221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26562212009-03-17 NOD-like receptors and inflammation Mathews, Rebeccah J Sprakes, Michael B McDermott, Michael F Arthritis Res Ther Review The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic diseases, as well as some more common polygenic conditions. Bacterial wall constituents and other cellular stressor molecules are recognized by a range of NLRs, which leads to activation of the innate immune response and upregulation of key proinflammatory pathways, such as IL-1β production and translocation of nuclear factor-κB to the nucleus. These signalling pathways are increasingly being targeted as potential sites for new therapies. This review discusses the role played by NLRs in a variety of inflammatory diseases and describes the remarkable success to date of these therapeutic agents in treating some of the disorders associated with aberrant NLR function. BioMed Central 2008 2008-11-25 /pmc/articles/PMC2656221/ /pubmed/19090963 http://dx.doi.org/10.1186/ar2525 Text en Copyright © 2008 BioMed Central Ltd |
spellingShingle | Review Mathews, Rebeccah J Sprakes, Michael B McDermott, Michael F NOD-like receptors and inflammation |
title | NOD-like receptors and inflammation |
title_full | NOD-like receptors and inflammation |
title_fullStr | NOD-like receptors and inflammation |
title_full_unstemmed | NOD-like receptors and inflammation |
title_short | NOD-like receptors and inflammation |
title_sort | nod-like receptors and inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656221/ https://www.ncbi.nlm.nih.gov/pubmed/19090963 http://dx.doi.org/10.1186/ar2525 |
work_keys_str_mv | AT mathewsrebeccahj nodlikereceptorsandinflammation AT sprakesmichaelb nodlikereceptorsandinflammation AT mcdermottmichaelf nodlikereceptorsandinflammation |