Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

INTRODUCTION: Treatment with sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been shown to be efficacious in the MRL/lpr and NZB × NZW F1 mouse models of lupus nephritis, indicating a critical role for the mTOR pathway in both models. This type of demonstration of efficacy in animal...

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Detalles Bibliográficos
Autores principales: Reddy, Padmalatha S, Legault, Holly M, Sypek, Joseph P, Collins, Mark J, Goad, Elizabeth, Goldman, Samuel J, Liu, Wei, Murray, Stuart, Dorner, Andrew J, O'Toole, Margot
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656226/
https://www.ncbi.nlm.nih.gov/pubmed/18980674
http://dx.doi.org/10.1186/ar2541

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