Cargando…

T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis

INTRODUCTION: T-614 is a novel oral antirheumatic agent for the treatment of rheumatoid arthritis. Whether it has immunomodulatory or disease-modifying properties and its mechanism of action are largely undetermined. METHODS: Rats with collagen-induced arthritis (CIA) were treated with T-614 (5 and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Fang, Lü, Liang-jing, Fu, Qiong, Dai, Min, Teng, Jia-lin, Fan, Wei, Chen, Shun-le, Ye, Ping, Shen, Nan, Huang, Xin-fang, Qian, Jie, Bao, Chun-de
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656239/ https://www.ncbi.nlm.nih.gov/pubmed/19019215 http://dx.doi.org/10.1186/ar2554

Ejemplares similares

Articular cartilage and changes in Arthritis: Collagen of articular cartilage
por: Eyre, David
Publicado: (2002)

Spermidine Inhibits Joints Inflammation and Macrophage Activation in Mice with Collagen-Induced Arthritis
por: Yuan, Hao, et al.
Publicado: (2021)

Intra-articular delivery of AAV vectors encoding PD-L1 attenuates joint inflammation and tissue damage in a mouse model of rheumatoid arthritis
por: Li, Wenjun, et al.
Publicado: (2023)

Lactobacillus fermentum PC1 has the Capacity to Attenuate Joint Inflammation in Collagen-Induced Arthritis in DBA/1 Mice
por: Esvaran, Meera, et al.
Publicado: (2019)

Protective effect of low dose intra-articular cadmium on inflammation and joint destruction in arthritis
por: Bonaventura, Paola, et al.
Publicado: (2017)

Humulus japonicus extract ameliorates collagen-induced arthritis in mice through regulation of overall articular inflammation
por: Kang, Eun-Jung, et al.
Publicado: (2020)

Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice
por: Deng, YongQi, et al.
Publicado: (2020)

Prevention of Immune Nephritis by the Small Molecular Weight Immunomodulator Iguratimod in MRL/lpr Mice
por: Yan, Qingran, et al.
Publicado: (2014)

Combined Treatment with Anisodamine and Neostigmine Inhibits Joint Inflammation in Collagen‐Induced Arthritis Mice
por: Zhou, Jv‐Xiang, et al.
Publicado: (2014)

Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus
por: Lawson, Brian R, et al.
Publicado: (2007)

Modulation of collagen-induced arthritis by adenovirus-mediated intra-articular expression of modified collagen type II
por: Tang, Bo, et al.
Publicado: (2010)

Effect of γ-tocotrienol in counteracting oxidative stress and joint damage in collagen-induced arthritis in rats
por: RADHAKRISHNAN, AMMU, et al.
Publicado: (2014)

Local Gene Transfer of OPG Prevents Joint Damage and Disease Progression in Collagen-Induced Arthritis
por: Zhang, Qingguo, et al.
Publicado: (2013)

Collagen Damage Location in Articular Cartilage Differs if Damage is Caused by Excessive Loading Magnitude or Rate
por: Henao-Murillo, Lorenza, et al.
Publicado: (2018)

Shexiang-Wulong Pills Attenuate Rheumatoid Arthritis by Alleviating Inflammation in a Mouse Model of Collagen-Induced Arthritis
por: Zhang, Zhihui, et al.
Publicado: (2019)

Mitochondria in Injury, Inflammation and Disease of Articular Skeletal Joints
por: Early, James Orman, et al.
Publicado: (2021)

Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis
por: Fang, Qinghua, et al.
Publicado: (2019)

Perforin deficiency attenuates collagen-induced arthritis
por: Bauer, Kristin, et al.
Publicado: (2005)

Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis
por: Fang, Qinghua, et al.
Publicado: (2020)

Wang-Bi Capsule Alleviates the Joint Inflammation and Bone Destruction in Mice with Collagen-Induced Arthritis
por: Cui, Hua, et al.
Publicado: (2020)

Blocking Interleukin-33 Alleviates the Joint Inflammation and Inhibits the Development of Collagen-Induced Arthritis in Mice
por: Li, Yan, et al.
Publicado: (2020)

Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation
por: Cheng, Yuli, et al.
Publicado: (2018)

T-614 attenuates knee osteoarthritis via regulating Wnt/β-catenin signaling pathway
por: Cong, Shan, et al.
Publicado: (2021)

Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis
por: O’Neil, Liam J., et al.
Publicado: (2020)

Predictors of joint damage in patients with rheumatoid arthritis: focus on short- and long-term effects of intra-articular glucocorticoid injections
por: Koh, Jung Hee, et al.
Publicado: (2021)

The minor collagens in articular cartilage
por: Luo, Yunyun, et al.
Publicado: (2017)

Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis
por: Sigalov, Alexander B.
Publicado: (2022)

Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan
por: Yoshimura, Sayuri, et al.
Publicado: (2014)

Sigesbeckia glabrescens Makino extract attenuated the collagen-induced arthritis through inhibiting the synovial hyperplasia and inflammation
por: Ma, Qiu Shuo, et al.
Publicado: (2020)

Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment
por: Elango, Jeevithan, et al.
Publicado: (2022)

Immunomodulation of Autoimmune Arthritis by Herbal CAM
por: Venkatesha, Shivaprasad H., et al.
Publicado: (2011)

Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis
por: Kehoe, Oksana, et al.
Publicado: (2014)

Mucin 1 aggravates synovitis and joint damage of rheumatoid arthritis by regulating inflammation and aggression of fibroblast-like synoviocytes
por: Zou, Yaoyao, et al.
Publicado: (2022)

Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis
por: Palmblad, Karin, et al.
Publicado: (2007)

Effects of inhaled cigarette smoke on the myo-articular system of female rats with collagen-induced arthritis
por: Moreira, Tayonara L., et al.
Publicado: (2011)

Proteoglycan loss in the articular cartilage is associated with severity of joint inflammation in psoriatic arthritis—a compositional magnetic resonance imaging study
por: Abrar, Daniel B., et al.
Publicado: (2020)

Obesity aggravates the joint inflammation in a collagen-induced arthritis model through deviation to Th17 differentiation
por: Jhun, Joo-Yeon, et al.
Publicado: (2012)

ES‐62 Protects Against Collagen‐Induced Arthritis by Resetting Interleukin‐22 Toward Resolution of Inflammation in the Joints
por: Pineda, Miguel A., et al.
Publicado: (2014)

Chemokine Receptor 5 Antagonism Causes Reduction in Joint Inflammation in a Collagen-Induced Arthritis Mouse Model
por: Ansari, Mushtaq A., et al.
Publicado: (2021)

The Relationship Between Proteoglycan Loss, Overloading-Induced Collagen Damage, and Cyclic Loading in Articular Cartilage
por: Henao-Murillo, Lorenza, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0ghe5r9ln2gnk8qohld27g9j4b