Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment

We report two patients with psychotic depression who were successfully treated with a lithium addition to ongoing paroxetine treatment. In both cases, plasma brain-derived neurotrophic factor (BDNF) levels increased about 2-fold after lithium augmentation to paroxetine, compared with paroxetine trea...

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Detalles Bibliográficos
Autores principales: Yoshimura, Reiji, Tsuji, Koshiro, Ueda, Nobuhisa, Nakamura, Jun
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2007
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656306/
https://www.ncbi.nlm.nih.gov/pubmed/19300599
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author Yoshimura, Reiji
Tsuji, Koshiro
Ueda, Nobuhisa
Nakamura, Jun
author_facet Yoshimura, Reiji
Tsuji, Koshiro
Ueda, Nobuhisa
Nakamura, Jun
author_sort Yoshimura, Reiji
collection PubMed
description We report two patients with psychotic depression who were successfully treated with a lithium addition to ongoing paroxetine treatment. In both cases, plasma brain-derived neurotrophic factor (BDNF) levels increased about 2-fold after lithium augmentation to paroxetine, compared with paroxetine treatment alone. Plasma paroxetine levels did not change after lithium addition. These results suggest that the increases in plasma BDNF levels reflect recovery from depressive symptoms in psychotic depression.
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spelling pubmed-26563062009-03-19 Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment Yoshimura, Reiji Tsuji, Koshiro Ueda, Nobuhisa Nakamura, Jun Neuropsychiatr Dis Treat Case Report We report two patients with psychotic depression who were successfully treated with a lithium addition to ongoing paroxetine treatment. In both cases, plasma brain-derived neurotrophic factor (BDNF) levels increased about 2-fold after lithium augmentation to paroxetine, compared with paroxetine treatment alone. Plasma paroxetine levels did not change after lithium addition. These results suggest that the increases in plasma BDNF levels reflect recovery from depressive symptoms in psychotic depression. Dove Medical Press 2007-10 /pmc/articles/PMC2656306/ /pubmed/19300599 Text en © 2007 Dove Medical Press Limited. All rights reserved
spellingShingle Case Report
Yoshimura, Reiji
Tsuji, Koshiro
Ueda, Nobuhisa
Nakamura, Jun
Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment
title Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment
title_full Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment
title_fullStr Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment
title_full_unstemmed Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment
title_short Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment
title_sort increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656306/
https://www.ncbi.nlm.nih.gov/pubmed/19300599
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