Cognitive decline tracks motor progression and not disease duration in Parkinson patients

We performed an analysis of prospectively-acquired cross sectional data on 106 Parkinson disease (PD) patients who underwent comprehensive neuropsychological testing and the Unified Parkinson Disease Rating Scale (UPDRS) motor scale. A significant correlation between the UPDRS motor and neuropsychol...

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Autores principales: Riggeal, BD, Crucian, GP, Seignourel, P, Jacobson, CE, Okun, MS, Rodriguez, RL, Fernandez, Hubert H
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2007
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656340/
https://www.ncbi.nlm.nih.gov/pubmed/19300633
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author Riggeal, BD
Crucian, GP
Seignourel, P
Jacobson, CE
Okun, MS
Rodriguez, RL
Fernandez, Hubert H
author_facet Riggeal, BD
Crucian, GP
Seignourel, P
Jacobson, CE
Okun, MS
Rodriguez, RL
Fernandez, Hubert H
author_sort Riggeal, BD
collection PubMed
description We performed an analysis of prospectively-acquired cross sectional data on 106 Parkinson disease (PD) patients who underwent comprehensive neuropsychological testing and the Unified Parkinson Disease Rating Scale (UPDRS) motor scale. A significant correlation between the UPDRS motor and neuropsychological tests in all cognitive domains except for general intelligence and visuo-spatial function was seen. In this study, cognitive decline within this PD cohort correlated with motor impairment but not disease duration. Our findings suggest that overall cognitive impairment (except visuospatial dysfunction) may track motor progression in PD more than duration of disease. Longitudinal studies are needed to confirm our results.
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spelling pubmed-26563402009-03-19 Cognitive decline tracks motor progression and not disease duration in Parkinson patients Riggeal, BD Crucian, GP Seignourel, P Jacobson, CE Okun, MS Rodriguez, RL Fernandez, Hubert H Neuropsychiatr Dis Treat Original Research We performed an analysis of prospectively-acquired cross sectional data on 106 Parkinson disease (PD) patients who underwent comprehensive neuropsychological testing and the Unified Parkinson Disease Rating Scale (UPDRS) motor scale. A significant correlation between the UPDRS motor and neuropsychological tests in all cognitive domains except for general intelligence and visuo-spatial function was seen. In this study, cognitive decline within this PD cohort correlated with motor impairment but not disease duration. Our findings suggest that overall cognitive impairment (except visuospatial dysfunction) may track motor progression in PD more than duration of disease. Longitudinal studies are needed to confirm our results. Dove Medical Press 2007-12 /pmc/articles/PMC2656340/ /pubmed/19300633 Text en © 2007 Dove Medical Press Limited. All rights reserved
spellingShingle Original Research
Riggeal, BD
Crucian, GP
Seignourel, P
Jacobson, CE
Okun, MS
Rodriguez, RL
Fernandez, Hubert H
Cognitive decline tracks motor progression and not disease duration in Parkinson patients
title Cognitive decline tracks motor progression and not disease duration in Parkinson patients
title_full Cognitive decline tracks motor progression and not disease duration in Parkinson patients
title_fullStr Cognitive decline tracks motor progression and not disease duration in Parkinson patients
title_full_unstemmed Cognitive decline tracks motor progression and not disease duration in Parkinson patients
title_short Cognitive decline tracks motor progression and not disease duration in Parkinson patients
title_sort cognitive decline tracks motor progression and not disease duration in parkinson patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656340/
https://www.ncbi.nlm.nih.gov/pubmed/19300633
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