Cargando…

Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide

INTRODUCTION: At physiologic concentration in serum, the bile acid sodium deoxycholate (DC) induces survival and migration of breast cancer cells. Here we provide evidence of a novel mechanism by which DC reduces apoptosis that is induced by the sphingolipid ceramide in breast cancer cells. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krishnamurthy, Kannan, Wang, Guanghu, Rokhfeld, Dmitriy, Bieberich, Erhard
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656903/ https://www.ncbi.nlm.nih.gov/pubmed/19087284 http://dx.doi.org/10.1186/bcr2211

Ejemplares similares

Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell–derived neural transplants
por: Bieberich, Erhard, et al.
Publicado: (2004)

Characterization of an apical ceramide-enriched compartment regulating ciliogenesis
por: He, Qian, et al.
Publicado: (2012)

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody
por: Jiang, Xue, et al.
Publicado: (2019)

Ceramide in Stem Cell Differentiation and Embryo Development: Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartments
por: Bieberich, Erhard
Publicado: (2011)

Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide
por: He, Qian, et al.
Publicado: (2014)

Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis
por: Tripathi, Priyanka, et al.
Publicado: (2021)

Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity
por: Elsherbini, Ahmed, et al.
Publicado: (2020)

Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3
por: Kong, Ji Na, et al.
Publicado: (2015)

Phytoceramide in Vertebrate Tissues: One Step Chromatography Separation for Molecular Characterization of Ceramide Species
por: Dasgupta, Somsankar, et al.
Publicado: (2013)

Exercise Promotes Pro-Apoptotic Ceramide Signaling in a Mouse Melanoma Model
por: Lee, Jonghae, et al.
Publicado: (2022)

Intrinsic, Pro-Apoptotic Effects of IGFBP-3 on Breast Cancer Cells are Reversible: Involvement of PKA, Rho, and Ceramide
por: Perks, Claire M., et al.
Publicado: (2011)

Critical Role of Spns2, a Sphingosine-1-Phosphate Transporter, in Lung Cancer Cell Survival and Migration
por: Bradley, Eric, et al.
Publicado: (2014)

Apoptotic Sphingolipid Ceramide in Cancer Therapy
por: Huang, Wei-Ching, et al.
Publicado: (2011)

Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide
por: Bieberich, Erhard, et al.
Publicado: (2003)

The pro- and antineoplastic effects of deoxycholic acid in pancreatic adenocarcinoma cell models
por: Schwarcz, Szandra, et al.
Publicado: (2023)

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles
por: Crivelli, Simone M., et al.
Publicado: (2022)

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression
por: Paschall, Amy V, et al.
Publicado: (2014)

Inhibition of ceramide accumulation in AdipoR1(–/–) mice increases photoreceptor survival and improves vision
por: Lewandowski, Dominik, et al.
Publicado: (2022)

Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development
por: Wang, G, et al.
Publicado: (2010)

The cocarcinogenic effect of intrarectal deoxycholate in rats is reduced by oral metronidazole.
por: Rainey, J. B., et al.
Publicado: (1984)

CERT(L) reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease
por: Crivelli, Simone M., et al.
Publicado: (2021)

Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis
por: Payne, Claire M, et al.
Publicado: (2011)

Sonic Hedgehog Promotes Tumor Cell Survival by Inhibiting CDON Pro-Apoptotic Activity
por: Delloye-Bourgeois, Céline, et al.
Publicado: (2013)

The pro-apoptotic role of autophagy in breast cancer
por: Suman, S, et al.
Publicado: (2014)

Identifying distinctive tissue and fecal microbial signatures and the tumor-promoting effects of deoxycholic acid on breast cancer
por: Wang, Na, et al.
Publicado: (2022)

Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-α, and JNK
por: Lew, Bark-Lynn, et al.
Publicado: (2006)

Cholecystectomy promotes colon carcinogenesis by activating the Wnt signaling pathway by increasing the deoxycholic acid level
por: Yao, Yuxia, et al.
Publicado: (2022)

Microbial metabolite deoxycholic acid promotes vasculogenic mimicry formation in intestinal carcinogenesis
por: Song, Xueli, et al.
Publicado: (2021)

Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein
por: Kemeny, Stav, et al.
Publicado: (2012)

Gene therapy for carcinoma of the breast: Pro-apoptotic gene therapy
por: Gómez-Navarro, Jesús, et al.
Publicado: (2000)

Carcinogenicity of deoxycholate, a secondary bile acid
por: Bernstein, Carol, et al.
Publicado: (2011)

Deoxycholic Acid Injections for Bra-Line Lipolysis
por: Jegasothy, S. Manjula
Publicado: (2018)

Topical formulation of sodium deoxycholate for submental lipolysis
por: Park, Hye Jeong, et al.
Publicado: (2023)

Correction: Cholecystectomy promotes colon carcinogenesis by activating the Wnt signaling pathway by increasing the deoxycholic acid level
por: Yao, Yuxia, et al.
Publicado: (2022)

EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival
por: Kang, Dong, et al.
Publicado: (2015)

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
por: Rutkowski, D. Thomas, et al.
Publicado: (2006)

Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis
por: Payne, Claire M., et al.
Publicado: (2009)

Cox regression and survival analysis from the tauro-urso-deoxycholic trial in amyotrophic lateral sclerosis
por: Reggiardo, Giorgio, et al.
Publicado: (2023)

Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules
por: Arababadi, Mohammad Kazemi, et al.
Publicado: (2016)

Sepsis: pro-apoptotic and anti-apoptotic signals in liver cells
por: Chatzigianni, EV, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_elp55v6s15657u5js8pkd35anb