Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells

[Image: see text] We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can delive...

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Detalles Bibliográficos
Autores principales: Chen, Xing, Wu, Peng, Rousseas, Michael, Okawa, David, Gartner, Zev, Zettl, Alex, Bertozzi, Carolyn R.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657038/
https://www.ncbi.nlm.nih.gov/pubmed/19119844
http://dx.doi.org/10.1021/ja807334b
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author Chen, Xing
Wu, Peng
Rousseas, Michael
Okawa, David
Gartner, Zev
Zettl, Alex
Bertozzi, Carolyn R.
author_facet Chen, Xing
Wu, Peng
Rousseas, Michael
Okawa, David
Gartner, Zev
Zettl, Alex
Bertozzi, Carolyn R.
author_sort Chen, Xing
collection PubMed
description [Image: see text] We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.
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spelling pubmed-26570382009-07-27 Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells Chen, Xing Wu, Peng Rousseas, Michael Okawa, David Gartner, Zev Zettl, Alex Bertozzi, Carolyn R. J Am Chem Soc [Image: see text] We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials. American Chemical Society 2009-01-02 2009-01-28 /pmc/articles/PMC2657038/ /pubmed/19119844 http://dx.doi.org/10.1021/ja807334b Text en Copyright © 2009 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Chen, Xing
Wu, Peng
Rousseas, Michael
Okawa, David
Gartner, Zev
Zettl, Alex
Bertozzi, Carolyn R.
Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells
title Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells
title_full Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells
title_fullStr Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells
title_full_unstemmed Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells
title_short Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells
title_sort boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657038/
https://www.ncbi.nlm.nih.gov/pubmed/19119844
http://dx.doi.org/10.1021/ja807334b
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