APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA

BACKGROUND: Naturally occurring Vif variants that are unable to inhibit the host restriction factor APOBEC3G (A3G) have been isolated from infected individuals. A3G can potentially induce G-to-A hypermutation in these viruses, and hypermutation could contribute to genetic variation in HIV-1 populati...

Descripción completa

Detalles Bibliográficos
Autores principales: Russell, Rebecca A, Moore, Michael D, Hu, Wei-Shau, Pathak, Vinay K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657108/
https://www.ncbi.nlm.nih.gov/pubmed/19216784
http://dx.doi.org/10.1186/1742-4690-6-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657108/
https://www.ncbi.nlm.nih.gov/pubmed/19216784
http://dx.doi.org/10.1186/1742-4690-6-16

Ejemplares similares