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Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: a comparison to functional outcome

BACKGROUND: Quantification of late gadolinium enhanced cardiovascular magnetic resonance (LGE CMR) by objective window setting increases reproducibility and facilitates multicenter comparison and cooperation. So far, quantification methods or models have only been validated to postmortem animal stud...

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Autores principales: Beek, Aernout M, Bondarenko, Olga, Afsharzada, Farshid, van Rossum, Albert C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657135/
https://www.ncbi.nlm.nih.gov/pubmed/19272147
http://dx.doi.org/10.1186/1532-429X-11-6
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author Beek, Aernout M
Bondarenko, Olga
Afsharzada, Farshid
van Rossum, Albert C
author_facet Beek, Aernout M
Bondarenko, Olga
Afsharzada, Farshid
van Rossum, Albert C
author_sort Beek, Aernout M
collection PubMed
description BACKGROUND: Quantification of late gadolinium enhanced cardiovascular magnetic resonance (LGE CMR) by objective window setting increases reproducibility and facilitates multicenter comparison and cooperation. So far, quantification methods or models have only been validated to postmortem animal studies. This study was undertaken to evaluate quantification of LGE in relation to the clinical standard of viability, i.e. functional outcome after revascularization. Thirty-eight patients with chronic ischemic myocardial dysfunction underwent cine and LGE 1 month before and cine CMR 6 months after coronary revascularization. Enhancement was quantified by thresholding window setting at: 2-8SD above mean signal intensity of a remote normal region, and according to the full width at half maximum method (FWHM). Dysfunctional segments were divided in 5 groups according to segmental extent of enhancement (SEE): SEE 1 – no enhancement to SEE 5 – 76–100% with each quantification method. RESULTS: Quantification methods had a strong influence on SEE and total infarct size. Multilevel analysis showed that thresholding contrast images at 6SD best predicted segmental functional outcome after revascularization, but the difference with other methods was small and non-significant. CONCLUSION: Simple thresholding techniques strongly influence global and segmental extent of LGE, but have relatively little influence on the accuracy to predict segmental functional improvement after revascularization.
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spelling pubmed-26571352009-03-18 Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: a comparison to functional outcome Beek, Aernout M Bondarenko, Olga Afsharzada, Farshid van Rossum, Albert C J Cardiovasc Magn Reson Research BACKGROUND: Quantification of late gadolinium enhanced cardiovascular magnetic resonance (LGE CMR) by objective window setting increases reproducibility and facilitates multicenter comparison and cooperation. So far, quantification methods or models have only been validated to postmortem animal studies. This study was undertaken to evaluate quantification of LGE in relation to the clinical standard of viability, i.e. functional outcome after revascularization. Thirty-eight patients with chronic ischemic myocardial dysfunction underwent cine and LGE 1 month before and cine CMR 6 months after coronary revascularization. Enhancement was quantified by thresholding window setting at: 2-8SD above mean signal intensity of a remote normal region, and according to the full width at half maximum method (FWHM). Dysfunctional segments were divided in 5 groups according to segmental extent of enhancement (SEE): SEE 1 – no enhancement to SEE 5 – 76–100% with each quantification method. RESULTS: Quantification methods had a strong influence on SEE and total infarct size. Multilevel analysis showed that thresholding contrast images at 6SD best predicted segmental functional outcome after revascularization, but the difference with other methods was small and non-significant. CONCLUSION: Simple thresholding techniques strongly influence global and segmental extent of LGE, but have relatively little influence on the accuracy to predict segmental functional improvement after revascularization. BioMed Central 2009-03-09 /pmc/articles/PMC2657135/ /pubmed/19272147 http://dx.doi.org/10.1186/1532-429X-11-6 Text en Copyright © 2009 Beek et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Beek, Aernout M
Bondarenko, Olga
Afsharzada, Farshid
van Rossum, Albert C
Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: a comparison to functional outcome
title Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: a comparison to functional outcome
title_full Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: a comparison to functional outcome
title_fullStr Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: a comparison to functional outcome
title_full_unstemmed Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: a comparison to functional outcome
title_short Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: a comparison to functional outcome
title_sort quantification of late gadolinium enhanced cmr in viability assessment in chronic ischemic heart disease: a comparison to functional outcome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657135/
https://www.ncbi.nlm.nih.gov/pubmed/19272147
http://dx.doi.org/10.1186/1532-429X-11-6
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