The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pr...

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Detalles Bibliográficos
Autores principales: Plant, Pamela J., Correa, Judy, Goldenberg, Neil, Bain, James, Batt, Jane
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2009
Materias:
Accelerated Publication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657291/
https://www.ncbi.nlm.nih.gov/pubmed/19125695
http://dx.doi.org/10.1042/BJ20081866
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author Plant, Pamela J.
Correa, Judy
Goldenberg, Neil
Bain, James
Batt, Jane
author_facet Plant, Pamela J.
Correa, Judy
Goldenberg, Neil
Bain, James
Batt, Jane
author_sort Plant, Pamela J.
collection PubMed
description The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.
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spelling pubmed-26572912009-03-30 The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4 Plant, Pamela J. Correa, Judy Goldenberg, Neil Bain, James Batt, Jane Biochem J Accelerated Publication The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown. Portland Press Ltd. 2009-03-13 2009-04-01 /pmc/articles/PMC2657291/ /pubmed/19125695 http://dx.doi.org/10.1042/BJ20081866 Text en © 2009 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by-nc/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Accelerated Publication
Plant, Pamela J.
Correa, Judy
Goldenberg, Neil
Bain, James
Batt, Jane
The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
title The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
title_full The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
title_fullStr The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
title_full_unstemmed The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
title_short The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
title_sort inositol phosphatase mtmr4 is a novel target of the ubiquitin ligase nedd4
topic Accelerated Publication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657291/
https://www.ncbi.nlm.nih.gov/pubmed/19125695
http://dx.doi.org/10.1042/BJ20081866
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