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Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation
The insulin and insulin-like growth factor 1 receptors activate overlapping signalling pathways that are critical for growth, metabolism, survival and longevity. Their mechanism of ligand binding and activation displays complex allosteric properties, which no mathematical model has been able to acco...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657531/ https://www.ncbi.nlm.nih.gov/pubmed/19225456 http://dx.doi.org/10.1038/msb.2008.78 |