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Nontuberculous Mycobacteria, Zambia

Clinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)–like disease. The proportion of NTM-positive sputum samples was significantly higher...

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Autores principales: Buijtels, Patricia C.A.M., van der Sande, Marianne A.B., de Graaff, Cas S., Parkinson, Shelagh, Verbrugh, Henri A., Petit, Pieter L.C., van Soolingen, Dick
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657609/
https://www.ncbi.nlm.nih.gov/pubmed/19193268
http://dx.doi.org/10.3201/eid1502.080006
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author Buijtels, Patricia C.A.M.
van der Sande, Marianne A.B.
de Graaff, Cas S.
Parkinson, Shelagh
Verbrugh, Henri A.
Petit, Pieter L.C.
van Soolingen, Dick
author_facet Buijtels, Patricia C.A.M.
van der Sande, Marianne A.B.
de Graaff, Cas S.
Parkinson, Shelagh
Verbrugh, Henri A.
Petit, Pieter L.C.
van Soolingen, Dick
author_sort Buijtels, Patricia C.A.M.
collection PubMed
description Clinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)–like disease. The proportion of NTM-positive sputum samples was significantly higher in the patient group than in controls; 11% and 6%, respectively (p<0.05). NTM-associated lung disease was diagnosed for 1 patient, and a probable diagnosis was made for 3 patients. NTM-positive patients and controls were more likely to report vomiting and diarrhea and were more frequently underweight than the NTM-negative patients and controls. Chest radiographs of NTM-positive patients showed deviations consistent with TB more frequently than those of controls. The most frequently isolated NTM was Mycobacterium avium complex. Multiple, not previously identified mycobacteria (55 of 171 NTM) were isolated from both groups. NTM probably play an important role in the etiology of TB-like diseases in Zambia.
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spelling pubmed-26576092009-03-30 Nontuberculous Mycobacteria, Zambia Buijtels, Patricia C.A.M. van der Sande, Marianne A.B. de Graaff, Cas S. Parkinson, Shelagh Verbrugh, Henri A. Petit, Pieter L.C. van Soolingen, Dick Emerg Infect Dis Research Clinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)–like disease. The proportion of NTM-positive sputum samples was significantly higher in the patient group than in controls; 11% and 6%, respectively (p<0.05). NTM-associated lung disease was diagnosed for 1 patient, and a probable diagnosis was made for 3 patients. NTM-positive patients and controls were more likely to report vomiting and diarrhea and were more frequently underweight than the NTM-negative patients and controls. Chest radiographs of NTM-positive patients showed deviations consistent with TB more frequently than those of controls. The most frequently isolated NTM was Mycobacterium avium complex. Multiple, not previously identified mycobacteria (55 of 171 NTM) were isolated from both groups. NTM probably play an important role in the etiology of TB-like diseases in Zambia. Centers for Disease Control and Prevention 2009-02 /pmc/articles/PMC2657609/ /pubmed/19193268 http://dx.doi.org/10.3201/eid1502.080006 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Buijtels, Patricia C.A.M.
van der Sande, Marianne A.B.
de Graaff, Cas S.
Parkinson, Shelagh
Verbrugh, Henri A.
Petit, Pieter L.C.
van Soolingen, Dick
Nontuberculous Mycobacteria, Zambia
title Nontuberculous Mycobacteria, Zambia
title_full Nontuberculous Mycobacteria, Zambia
title_fullStr Nontuberculous Mycobacteria, Zambia
title_full_unstemmed Nontuberculous Mycobacteria, Zambia
title_short Nontuberculous Mycobacteria, Zambia
title_sort nontuberculous mycobacteria, zambia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657609/
https://www.ncbi.nlm.nih.gov/pubmed/19193268
http://dx.doi.org/10.3201/eid1502.080006
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