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The aprotinin saga and the risks of conducting meta-analyses on small randomised controlled trials – a critique of a Cochrane review

BACKGROUND: Aprotinin for reducing blood loss during coronary artery bypass surgery was withdrawn from the market after early termination of a large randomised controlled trial (RCT) showing excess mortality for patients receiving aprotinin compared to lysine analogues. Several meta-analyses of smal...

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Detalles Bibliográficos
Autor principal:	Rosén, Måns
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Correspondence
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657782/ https://www.ncbi.nlm.nih.gov/pubmed/19228407 http://dx.doi.org/10.1186/1472-6963-9-34

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