Red blood cell glutathione peroxidase activity in female nulligravid and pregnant rats

BACKGROUND: The alterations of the glutathione peroxidase enzyme complex system occur in physiological conditions such as aging and oxidative stress consequent to strenuous exercise. METHODS: Authors optimize the spectrophotometric method to measure glutathione peroxidase activity in rat red blood c...

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Detalles Bibliográficos
Autores principales: Gallo, Giuseppe, Martino, Guglielmo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657797/
https://www.ncbi.nlm.nih.gov/pubmed/19171040
http://dx.doi.org/10.1186/1477-7827-7-7
Descripción
Sumario:BACKGROUND: The alterations of the glutathione peroxidase enzyme complex system occur in physiological conditions such as aging and oxidative stress consequent to strenuous exercise. METHODS: Authors optimize the spectrophotometric method to measure glutathione peroxidase activity in rat red blood cell membranes. RESULTS: The optimization, when applied to age paired rats, both nulligravid and pregnant, shows that pregnancy induces, at seventeen d of pregnancy, an increase of both reactive oxygen substance concentration in red blood cells and membrane glutathione peroxidase activity. CONCLUSION: The glutathione peroxidase increase in erythrocyte membranes is induced by systemic oxidative stress long lasting rat pregnancy.

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