Novel Anti-Metastatic Action of Cidofovir Mediated by Inhibition of E6/E7, CXCR4 and Rho/ROCK Signaling in HPV(+) Tumor Cells

Cervical cancer is frequently associated with HPV infection. The expression of E6 and E7 HPV oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. The cellular mechanisms involved in metastatic spread remain elusive, but pro-adhe...

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Detalles Bibliográficos
Autores principales: Amine, Abdessamad, Rivera, Sofia, Opolon, Paule, Dekkal, Mehdi, Biard, Denis S. F., Bouamar, Hakim, Louache, Fawzia, McKay, Michael J., Bourhis, Jean, Deutsch, Eric, Vozenin-Brotons, Marie-Catherine
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657827/
https://www.ncbi.nlm.nih.gov/pubmed/19325708
http://dx.doi.org/10.1371/journal.pone.0005018

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