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Biochemical, Functional, and Pharmacological Characterization of AT-56, an Orally Active and Selective Inhibitor of Lipocalin-type Prostaglandin D Synthase

We report here that 4-dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine (AT-56) is an orally active and selective inhibitor of lipocalin-type prostaglandin (PG) D synthase (L-PGDS). AT-56 inhibited human and mouse L-PGDSs in a concentration (3–250 μm)-dependent manner but d...

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Detalles Bibliográficos
Autores principales:	Irikura, Daisuke, Aritake, Kosuke, Nagata, Nanae, Maruyama, Toshihiko, Shimamoto, Shigeru, Urade, Yoshihiro
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658056/ https://www.ncbi.nlm.nih.gov/pubmed/19131342 http://dx.doi.org/10.1074/jbc.M808593200

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