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Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

Human coxsackievirus (CV) belongs to the picornavirus family, which consists of over 200 medically relevant viruses. In picornavirus, a chymotrypsin-like protease (3C(pro)) is required for viral replication by processing the polyproteins, and thus it is regarded as an antiviral drug target. A 3C-lik...

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Detalles Bibliográficos
Autores principales:	Lee, Cheng-Chung, Kuo, Chih-Jung, Ko, Tzu-Ping, Hsu, Min-Feng, Tsui, Yao-Chen, Chang, Shih-Cheng, Yang, Syaulan, Chen, Shu-Jen, Chen, Hua-Chien, Hsu, Ming-Chu, Shih, Shin-Ru, Liang, Po-Huang, Wang, Andrew H.-J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658058/ https://www.ncbi.nlm.nih.gov/pubmed/19144641 http://dx.doi.org/10.1074/jbc.M807947200

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