Cargando…

Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

ATP-binding cassette transporters play an important role in drug resistance and nutrient transport. In the human malaria parasite Plasmodium falciparum, a homolog of the human p-glycoprotein (PfPgh-1) was shown to be involved in resistance to several drugs. More recently, many transporters were asso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raj, Dipak Kumar, Mu, Jianbing, Jiang, Hongying, Kabat, Juraj, Singh, Subash, Sullivan, Margery, Fay, Michael P., McCutchan, Thomas F., Su, Xin-zhuan
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Membrane Transport, Structure, Function, and Biogenesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658063/ https://www.ncbi.nlm.nih.gov/pubmed/19117944 http://dx.doi.org/10.1074/jbc.M806944200

Ejemplares similares

Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
por: Kavishe, Reginald A, et al.
Publicado: (2009)

Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein
por: Bose, Mahuya, et al.
Publicado: (2008)

Identification of Pore Residues Engaged in Determining Divalent Cationic Permeation in Transient Receptor Potential Melastatin Subtype Channel 2
por: Xia, Rong, et al.
Publicado: (2008)

Time-resolved Mechanism of Extracellular Gate Opening and Substrate Binding in a Glutamate Transporter
por: Shrivastava, Indira H., et al.
Publicado: (2008)

The Reticulon and Dp1/Yop1p Proteins Form Immobile Oligomers in the Tubular Endoplasmic Reticulum
por: Shibata, Yoko, et al.
Publicado: (2008)

An Unconventional Diacylglycerol Kinase That Regulates Phospholipid Synthesis and Nuclear Membrane Growth
por: Han, Gil-Soo, et al.
Publicado: (2008)

Structural Determinants of Ca(2+) Permeability and Conduction in the Human 5-Hydroxytryptamine Type 3A Receptor
por: Livesey, Matthew R., et al.
Publicado: (2008)

Analysis of Polypeptide Movement in the SecY Channel during SecA-mediated Protein Translocation
por: Erlandson, Karl J., et al.
Publicado: (2008)

Permeation Properties of a P2X Receptor in the Green Algae Ostreococcus tauri
por: Fountain, Samuel J., et al.
Publicado: (2008)

Intermediate Phosphorylation Reactions in the Mechanism of ATP Utilization by the Copper ATPase (CopA) of Thermotoga maritima
por: Hatori, Yuta, et al.
Publicado: (2008)

Rab3GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes
por: Figueiredo, Ana C., et al.
Publicado: (2008)

Molecular Shape, Architecture, and Size of P2X(4) Receptors Determined Using Fluorescence Resonance Energy Transfer and Electron Microscopy
por: Young, Mark T., et al.
Publicado: (2008)

Crystal Structure of Soluble Domain of Malaria Sporozoite Protein UIS3 in Complex with Lipid
por: Sharma, Ashwani, et al.
Publicado: (2008)

AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals
por: Nikaido, Eiji, et al.
Publicado: (2008)

Analysis of the Synaptotagmin Family during Reconstituted Membrane Fusion: UNCOVERING A CLASS OF INHIBITORY ISOFORMS
por: Bhalla, Akhil, et al.
Publicado: (2008)

Nonmitochondrial ATP/ADP Transporters Accept Phosphate as Third Substrate
por: Trentmann, Oliver, et al.
Publicado: (2008)

MacB ABC Transporter Is a Dimer Whose ATPase Activity and Macrolide-binding Capacity Are Regulated by the Membrane Fusion Protein MacA
por: Lin, Hong Ting, et al.
Publicado: (2009)

Cell Entry of Arginine-rich Peptides Is Independent of Endocytosis
por: Ter-Avetisyan, Gohar, et al.
Publicado: (2009)

Mechanistic Insight into Control of CFTR by AMPK
por: Kongsuphol, Patthara, et al.
Publicado: (2009)

The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion
por: Hinson, Ella R., et al.
Publicado: (2009)

Interaction of the Aromatics Tyr-72/Trp-288 in the Interface of the Extracellular and Transmembrane Domains Is Essential for Proton Gating of Acid-sensing Ion Channels
por: Li, Tianbo, et al.
Publicado: (2009)

The Cytoskeletal Protein α-Actinin Regulates Acid-sensing Ion Channel 1a through a C-terminal Interaction
por: Schnizler, Mikael K., et al.
Publicado: (2009)

PICK1-mediated Glutamate Receptor Subunit 2 (GluR2) Trafficking Contributes to Cell Death in Oxygen/Glucose-deprived Hippocampal Neurons
por: Dixon, Rebecca M., et al.
Publicado: (2009)

High Yield Heterologous Expression of Wild-type and Mutant Cu(+)-ATPase (ATP7B, Wilson Disease Protein) for Functional Characterization of Catalytic Activity and Serine Residues Undergoing Copper-dependent Phosphorylation
por: Pilankatta, Rajendra, et al.
Publicado: (2009)

Glutamine 57 at the Complementary Binding Site Face Is a Key Determinant of Morantel Selectivity for α7 Nicotinic Receptors
por: Bartos, Mariana, et al.
Publicado: (2009)

Three-dimensional Structure of Ca(V)3.1: COMPARISON WITH THE CARDIAC L-TYPE VOLTAGE-GATED CALCIUM CHANNEL MONOMER ARCHITECTURE
por: Walsh, Conor P., et al.
Publicado: (2009)

cAMP Stimulates Apical Exocytosis of the Renal Na(+)-K(+)-2Cl(−) Cotransporter NKCC2 in the Thick Ascending Limb: ROLE OF PROTEIN KINASE A
por: Caceres, Paulo S., et al.
Publicado: (2009)

Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle
por: Wilson, Marieangela C., et al.
Publicado: (2009)

Subunit Organization in the TatA Complex of the Twin Arginine Protein Translocase: A SITE-DIRECTED EPR SPIN LABELING STUDY
por: White, Gaye F., et al.
Publicado: (2010)

Ricin A Chain Insertion into Endoplasmic Reticulum Membranes Is Triggered by a Temperature Increase to 37 °C
por: Mayerhofer, Peter U., et al.
Publicado: (2009)

Regulation of the Epithelial Na(+) Channel by the Protein Kinase CK2
por: Bachhuber, Tanja, et al.
Publicado: (2008)

Functional Expression of the Na-K-2Cl Cotransporter NKCC2 in Mammalian Cells Fails to Confirm the Dominant-negative Effect of the AF Splice Variant
por: Hannemann, Anke, et al.
Publicado: (2009)

Energy-dependent Immunity Protein Release during tol-dependent Nuclease Colicin Translocation
por: Vankemmelbeke, Mireille, et al.
Publicado: (2009)

Kinetic Evidence for Unique Regulation of GLUT4 Trafficking by Insulin and AMP-activated Protein Kinase Activators in L6 Myotubes
por: Fazakerley, Daniel J., et al.
Publicado: (2010)

Structure and Function of Colicin S4, a Colicin with a Duplicated Receptor-binding Domain
por: Arnold, Thomas, et al.
Publicado: (2009)

D-AKAP2 Interacts with Rab4 and Rab11 through Its RGS Domains and Regulates Transferrin Receptor Recycling
por: Eggers, Christopher T., et al.
Publicado: (2009)

Functional Characterization of Intracellular Dictyostelium discoideum P2X Receptors
por: Ludlow, Melanie J., et al.
Publicado: (2009)

The Missing Link in Coronavirus Assembly: RETENTION OF THE AVIAN CORONAVIRUS INFECTIOUS BRONCHITIS VIRUS ENVELOPE PROTEIN IN THE PRE-GOLGI COMPARTMENTS AND PHYSICAL INTERACTION BETWEEN THE ENVELOPE AND MEMBRANE PROTEINS
por: Lim, K.P., et al.
Publicado: (2001)

Coronavirus Replication Complex Formation Utilizes Components of Cellular Autophagy
por: Prentice, Erik, et al.
Publicado: (2004)

A Novel Sorting Signal for Intracellular Localization Is Present in the S Protein of a Porcine Coronavirus but Absent from Severe Acute Respiratory Syndrome-associated Coronavirus
por: Schwegmann-Wessels, Christel, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_ii42q9n7cqgncmrfs93fi16s8k