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Dietary glycemic load and gastric cancer risk in Italy

We investigated gastric cancer risk in relation to dietary glycemic index (GI) and glycemic load (GL), which represent indirect measures of carbohydrate absorption and consequently of dietary insulin demand, in a case-control study conducted in northern Italy between 1997 and 2007, including 230 pat...

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Autores principales: Bertuccio, P, Praud, D, Chatenoud, L, Lucenteforte, E, Bosetti, C, Pelucchi, C, Rossi, M, Negri, E, La Vecchia, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658547/
https://www.ncbi.nlm.nih.gov/pubmed/19190635
http://dx.doi.org/10.1038/sj.bjc.6604894
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author Bertuccio, P
Praud, D
Chatenoud, L
Lucenteforte, E
Bosetti, C
Pelucchi, C
Rossi, M
Negri, E
La Vecchia, C
author_facet Bertuccio, P
Praud, D
Chatenoud, L
Lucenteforte, E
Bosetti, C
Pelucchi, C
Rossi, M
Negri, E
La Vecchia, C
author_sort Bertuccio, P
collection PubMed
description We investigated gastric cancer risk in relation to dietary glycemic index (GI) and glycemic load (GL), which represent indirect measures of carbohydrate absorption and consequently of dietary insulin demand, in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with the incident, histologically confirmed gastric cancer and 547 frequency matched controls, admitted to the same hospitals as cases with acute non-neoplastic conditions. We used conditional logistic regression models, including terms for major recognised gastric cancer risk factors and non-carbohydrate energy intake. The odds ratios (ORs) in the highest vs lowest quintile were 1.9 (95% CI: 1.0–3.3) for GI and 2.5 (95% CI: 1.3–4.9) for GL. Compared with participants reporting low GL and high fruits/vegetables intake, the OR rose across strata of high GL and low fruits/vegetables, to reach 5.0 (95% CI: 2.2–11.5) for those reporting low fruits/vegetables intake and high GL. Our study may help to explain the direct relation observed in several studies between starchy foods and gastric cancer risk.
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spelling pubmed-26585472010-02-10 Dietary glycemic load and gastric cancer risk in Italy Bertuccio, P Praud, D Chatenoud, L Lucenteforte, E Bosetti, C Pelucchi, C Rossi, M Negri, E La Vecchia, C Br J Cancer Epidemiology We investigated gastric cancer risk in relation to dietary glycemic index (GI) and glycemic load (GL), which represent indirect measures of carbohydrate absorption and consequently of dietary insulin demand, in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with the incident, histologically confirmed gastric cancer and 547 frequency matched controls, admitted to the same hospitals as cases with acute non-neoplastic conditions. We used conditional logistic regression models, including terms for major recognised gastric cancer risk factors and non-carbohydrate energy intake. The odds ratios (ORs) in the highest vs lowest quintile were 1.9 (95% CI: 1.0–3.3) for GI and 2.5 (95% CI: 1.3–4.9) for GL. Compared with participants reporting low GL and high fruits/vegetables intake, the OR rose across strata of high GL and low fruits/vegetables, to reach 5.0 (95% CI: 2.2–11.5) for those reporting low fruits/vegetables intake and high GL. Our study may help to explain the direct relation observed in several studies between starchy foods and gastric cancer risk. Nature Publishing Group 2009-02-10 2009-02-03 /pmc/articles/PMC2658547/ /pubmed/19190635 http://dx.doi.org/10.1038/sj.bjc.6604894 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Bertuccio, P
Praud, D
Chatenoud, L
Lucenteforte, E
Bosetti, C
Pelucchi, C
Rossi, M
Negri, E
La Vecchia, C
Dietary glycemic load and gastric cancer risk in Italy
title Dietary glycemic load and gastric cancer risk in Italy
title_full Dietary glycemic load and gastric cancer risk in Italy
title_fullStr Dietary glycemic load and gastric cancer risk in Italy
title_full_unstemmed Dietary glycemic load and gastric cancer risk in Italy
title_short Dietary glycemic load and gastric cancer risk in Italy
title_sort dietary glycemic load and gastric cancer risk in italy
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658547/
https://www.ncbi.nlm.nih.gov/pubmed/19190635
http://dx.doi.org/10.1038/sj.bjc.6604894
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