Cargando…
An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England
Patients diagnosed in 1960–2004 with cancer of the cervix, anus, vulva, vagina or penis were identified from the Thames Cancer Registry database, and age-standardised period (temporal) incidence rates calculated by direct standardisation. Age-cohort modelling techniques were used to estimate age-spe...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658550/ https://www.ncbi.nlm.nih.gov/pubmed/19156144 http://dx.doi.org/10.1038/sj.bjc.6604871 |
_version_ | 1782165641909764096 |
---|---|
author | Robinson, D Coupland, V Møller, H |
author_facet | Robinson, D Coupland, V Møller, H |
author_sort | Robinson, D |
collection | PubMed |
description | Patients diagnosed in 1960–2004 with cancer of the cervix, anus, vulva, vagina or penis were identified from the Thames Cancer Registry database, and age-standardised period (temporal) incidence rates calculated by direct standardisation. Age-cohort modelling techniques were used to estimate age-specific incidence rates in the earlier and later cohorts, enabling the calculation of age-standardised cohort (generational) rates. Incidence of anal cancer increased for both men and women over the period studied, mainly in those born from 1940 onwards. Similar generational patterns were seen for cancers of the vulva and vagina, but those for penile cancer were different. For cervix cancer, the steep downward trend in cohort rates due to screening levelled off in women born from 1940 onwards. Our findings are compatible with the hypothesis that changes in sexual practices were a major contributor to the increases of these cancers. Programmes of vaccination against HPV, aimed at reducing the burden of cervical cancer, may also help to reduce the incidence of cancer at other anogenital sites. |
format | Text |
id | pubmed-2658550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-26585502010-02-10 An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England Robinson, D Coupland, V Møller, H Br J Cancer Epidemiology Patients diagnosed in 1960–2004 with cancer of the cervix, anus, vulva, vagina or penis were identified from the Thames Cancer Registry database, and age-standardised period (temporal) incidence rates calculated by direct standardisation. Age-cohort modelling techniques were used to estimate age-specific incidence rates in the earlier and later cohorts, enabling the calculation of age-standardised cohort (generational) rates. Incidence of anal cancer increased for both men and women over the period studied, mainly in those born from 1940 onwards. Similar generational patterns were seen for cancers of the vulva and vagina, but those for penile cancer were different. For cervix cancer, the steep downward trend in cohort rates due to screening levelled off in women born from 1940 onwards. Our findings are compatible with the hypothesis that changes in sexual practices were a major contributor to the increases of these cancers. Programmes of vaccination against HPV, aimed at reducing the burden of cervical cancer, may also help to reduce the incidence of cancer at other anogenital sites. Nature Publishing Group 2009-02-10 2009-01-20 /pmc/articles/PMC2658550/ /pubmed/19156144 http://dx.doi.org/10.1038/sj.bjc.6604871 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Robinson, D Coupland, V Møller, H An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England |
title | An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England |
title_full | An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England |
title_fullStr | An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England |
title_full_unstemmed | An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England |
title_short | An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England |
title_sort | analysis of temporal and generational trends in the incidence of anal and other hpv-related cancers in southeast england |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658550/ https://www.ncbi.nlm.nih.gov/pubmed/19156144 http://dx.doi.org/10.1038/sj.bjc.6604871 |
work_keys_str_mv | AT robinsond ananalysisoftemporalandgenerationaltrendsintheincidenceofanalandotherhpvrelatedcancersinsoutheastengland AT couplandv ananalysisoftemporalandgenerationaltrendsintheincidenceofanalandotherhpvrelatedcancersinsoutheastengland AT møllerh ananalysisoftemporalandgenerationaltrendsintheincidenceofanalandotherhpvrelatedcancersinsoutheastengland AT robinsond analysisoftemporalandgenerationaltrendsintheincidenceofanalandotherhpvrelatedcancersinsoutheastengland AT couplandv analysisoftemporalandgenerationaltrendsintheincidenceofanalandotherhpvrelatedcancersinsoutheastengland AT møllerh analysisoftemporalandgenerationaltrendsintheincidenceofanalandotherhpvrelatedcancersinsoutheastengland |