Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

It has been proposed that inhibitors of an oncogene's effects on multipotent hematopoietic progenitor cell differentiation may change the properties of the leukemic stem cells and complement the clinical use of cytotoxic drugs. Using zebrafish, we developed a robust in vivo hematopoietic differ...

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Detalles Bibliográficos
Autores principales: Yeh, Jing-Ruey J., Munson, Kathleen M., Elagib, Kamaleldin E., Goldfarb, Adam N., Sweetser, David A., Peterson, Randall T.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658727/
https://www.ncbi.nlm.nih.gov/pubmed/19172146
http://dx.doi.org/10.1038/nchembio.147
Descripción
Sumario:It has been proposed that inhibitors of an oncogene's effects on multipotent hematopoietic progenitor cell differentiation may change the properties of the leukemic stem cells and complement the clinical use of cytotoxic drugs. Using zebrafish, we developed a robust in vivo hematopoietic differentiation assay that reflects the activity of the oncogene AML1-ETO. Screening for modifiers of AML1-ETO-mediated hematopoietic dysregulation uncovered unexpected roles of COX-2 and β-catenin-dependent pathways in AML1-ETO function. This approach may open doors for developing therapeutics targeting oncogene function within leukemic stem cells.

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