Cargando…

In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress

Sodium nitrite (NaNO(2)), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO(2)-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO(2) treatment for a period of thr...

Descripción completa

Detalles Bibliográficos
Autores principales: Hassan, Hanaa A, El-Agmy, Sherif M, Gaur, Rajiv L, Fernando, Augusta, Raj, Madhwa HG, Ouhtit, Allal
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659008/
https://www.ncbi.nlm.nih.gov/pubmed/19305642
_version_ 1782165659476557824
author Hassan, Hanaa A
El-Agmy, Sherif M
Gaur, Rajiv L
Fernando, Augusta
Raj, Madhwa HG
Ouhtit, Allal
author_facet Hassan, Hanaa A
El-Agmy, Sherif M
Gaur, Rajiv L
Fernando, Augusta
Raj, Madhwa HG
Ouhtit, Allal
author_sort Hassan, Hanaa A
collection PubMed
description Sodium nitrite (NaNO(2)), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO(2)-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO(2) treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress.
format Text
id pubmed-2659008
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-26590082009-03-20 In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress Hassan, Hanaa A El-Agmy, Sherif M Gaur, Rajiv L Fernando, Augusta Raj, Madhwa HG Ouhtit, Allal Int J Biol Sci Research Paper Sodium nitrite (NaNO(2)), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO(2)-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO(2) treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress. Ivyspring International Publisher 2009-03-10 /pmc/articles/PMC2659008/ /pubmed/19305642 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Hassan, Hanaa A
El-Agmy, Sherif M
Gaur, Rajiv L
Fernando, Augusta
Raj, Madhwa HG
Ouhtit, Allal
In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
title In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
title_full In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
title_fullStr In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
title_full_unstemmed In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
title_short In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
title_sort in vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659008/
https://www.ncbi.nlm.nih.gov/pubmed/19305642
work_keys_str_mv AT hassanhanaaa invivoevidenceofhepatoandrenoprotectiveeffectofgarlicoilagainstsodiumnitriteinducedoxidativestress
AT elagmysherifm invivoevidenceofhepatoandrenoprotectiveeffectofgarlicoilagainstsodiumnitriteinducedoxidativestress
AT gaurrajivl invivoevidenceofhepatoandrenoprotectiveeffectofgarlicoilagainstsodiumnitriteinducedoxidativestress
AT fernandoaugusta invivoevidenceofhepatoandrenoprotectiveeffectofgarlicoilagainstsodiumnitriteinducedoxidativestress
AT rajmadhwahg invivoevidenceofhepatoandrenoprotectiveeffectofgarlicoilagainstsodiumnitriteinducedoxidativestress
AT ouhtitallal invivoevidenceofhepatoandrenoprotectiveeffectofgarlicoilagainstsodiumnitriteinducedoxidativestress