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In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
Sodium nitrite (NaNO(2)), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO(2)-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO(2) treatment for a period of thr...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659008/ https://www.ncbi.nlm.nih.gov/pubmed/19305642 |
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author | Hassan, Hanaa A El-Agmy, Sherif M Gaur, Rajiv L Fernando, Augusta Raj, Madhwa HG Ouhtit, Allal |
author_facet | Hassan, Hanaa A El-Agmy, Sherif M Gaur, Rajiv L Fernando, Augusta Raj, Madhwa HG Ouhtit, Allal |
author_sort | Hassan, Hanaa A |
collection | PubMed |
description | Sodium nitrite (NaNO(2)), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO(2)-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO(2) treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress. |
format | Text |
id | pubmed-2659008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-26590082009-03-20 In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress Hassan, Hanaa A El-Agmy, Sherif M Gaur, Rajiv L Fernando, Augusta Raj, Madhwa HG Ouhtit, Allal Int J Biol Sci Research Paper Sodium nitrite (NaNO(2)), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO(2)-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO(2) treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress. Ivyspring International Publisher 2009-03-10 /pmc/articles/PMC2659008/ /pubmed/19305642 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Research Paper Hassan, Hanaa A El-Agmy, Sherif M Gaur, Rajiv L Fernando, Augusta Raj, Madhwa HG Ouhtit, Allal In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
title | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
title_full | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
title_fullStr | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
title_full_unstemmed | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
title_short | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
title_sort | in vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659008/ https://www.ncbi.nlm.nih.gov/pubmed/19305642 |
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