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Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth

The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development...

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Detalles Bibliográficos
Autores principales:	Rezgui, Dellel, Williams, Christopher, Savage, Sharon A, Prince, Stuart N, Zaccheo, Oliver J, Jones, E Yvonne, Crump, Matthew P, Hassan, A Bassim
Formato:	Texto
Lenguaje:	English
Publicado:	Society for Endocrinology 2009
Materias:	Regular papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659294/ https://www.ncbi.nlm.nih.gov/pubmed/19208780 http://dx.doi.org/10.1677/JME-08-0154

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