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Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
Chk1 is a serine/threonine protein kinase which is activated by a wide range of DNA damaging agents in order to slow the cell cycle during S phase and G2/M. Abrogation of these cell cycle checkpoints using Chk1 inhibitors results in hypersensitivity to DNA damaging agents in vitro and may provide a...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659326/ https://www.ncbi.nlm.nih.gov/pubmed/19169280 http://dx.doi.org/10.1038/onc.2008.482 |