Loss of Metal Ions, Disulfide Reduction and Mutations Related to Familial ALS Promote Formation of Amyloid-Like Aggregates from Superoxide Dismutase

Mutations in the gene encoding Cu-Zn superoxide dismutase (SOD1) are one of the causes of familial amyotrophic lateral sclerosis (FALS). Fibrillar inclusions containing SOD1 and SOD1 inclusions that bind the amyloid-specific dye thioflavin S have been found in neurons of transgenic mice expressing m...

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Detalles Bibliográficos
Autores principales: Oztug Durer, Zeynep A., Cohlberg, Jeffrey A., Dinh, Phong, Padua, Shelby, Ehrenclou, Krista, Downes, Sean, Tan, James K., Nakano, Yoko, Bowman, Christopher J., Hoskins, Jessica L., Kwon, Chuhee, Mason, Andrew Z., Rodriguez, Jorge A., Doucette, Peter A., Shaw, Bryan F., Valentine, Joan Selverstone
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659422/
https://www.ncbi.nlm.nih.gov/pubmed/19325915
http://dx.doi.org/10.1371/journal.pone.0005004

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