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Comparison of Replication-Competent, First Generation, and Helper-Dependent Adenoviral Vaccines

All studies using human serotype 5 Adenovirus (Ad) vectors must address two major obstacles: safety and the presence of pre-existing neutralizing antibodies. Helper-Dependent (HD) Ads have been proposed as alternative vectors for gene therapy and vaccine development because they have an improved saf...

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Detalles Bibliográficos
Autores principales:	Weaver, Eric A., Nehete, Pramod N., Buchl, Stephanie S., Senac, Julien S., Palmer, Donna, Ng, Philip, Sastry, K. Jagannadha, Barry, Michael A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659436/ https://www.ncbi.nlm.nih.gov/pubmed/19333387 http://dx.doi.org/10.1371/journal.pone.0005059

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