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Inefficient Quality Control of Thermosensitive Proteins on the Plasma Membrane

BACKGROUND: Misfolded proteins are generally recognised by cellular quality control machinery, which typically results in their ubiquitination and degradation. For soluble cytoplasmic proteins, degradation is mediated by the proteasome. Membrane proteins that fail to fold correctly are subject to ER...

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Detalles Bibliográficos
Autores principales: Lewis, Michael J., Pelham, Hugh R. B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659772/
https://www.ncbi.nlm.nih.gov/pubmed/19337370
http://dx.doi.org/10.1371/journal.pone.0005038