CDKN1C (p57(KIP2)) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells

CDKN1C (encoding tumor suppressor p57(KIP2)) is a cyclin-dependent kinase (CDK) inhibitor whose family members are often transcriptionally downregulated in human cancer via promoter DNA methylation. In this study, we show that CDKN1C is repressed in breast cancer cells mainly through histone modific...

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Detalles Bibliográficos
Autores principales: Yang, Xiaojing, Karuturi, R. K. Murthy, Sun, Feng, Aau, Meiyee, Yu, Kun, Shao, Rongguang, Miller, Lance D., Tan, Patrick Boon Ooi, Yu, Qiang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659786/
https://www.ncbi.nlm.nih.gov/pubmed/19340297
http://dx.doi.org/10.1371/journal.pone.0005011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659786/
https://www.ncbi.nlm.nih.gov/pubmed/19340297
http://dx.doi.org/10.1371/journal.pone.0005011

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