Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen(K164R) mutant mice

Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a critical replication factor. In contrast to high-fidelity DNA polymerases, the activation of low-fidelity translesion synthesis (TLS) DNA polymera...

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Detalles Bibliográficos
Autores principales: Langerak, Petra, Krijger, Peter H.L., Heideman, Marinus R., van den Berk, Paul C.M., Jacobs, Heinz
Formato: Texto
Lenguaje:English
Publicado: The Royal Society 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660925/
https://www.ncbi.nlm.nih.gov/pubmed/19008189
http://dx.doi.org/10.1098/rstb.2008.0223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660925/
https://www.ncbi.nlm.nih.gov/pubmed/19008189
http://dx.doi.org/10.1098/rstb.2008.0223

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