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Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen(K164R) mutant mice

Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a critical replication factor. In contrast to high-fidelity DNA polymerases, the activation of low-fidelity translesion synthesis (TLS) DNA polymera...

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Detalles Bibliográficos
Autores principales:	Langerak, Petra, Krijger, Peter H.L., Heideman, Marinus R., van den Berk, Paul C.M., Jacobs, Heinz
Formato:	Texto
Lenguaje:	English
Publicado:	The Royal Society 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660925/ https://www.ncbi.nlm.nih.gov/pubmed/19008189 http://dx.doi.org/10.1098/rstb.2008.0223

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