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Phase I and Pharmacokinetic Study of HER2-targeted rhuMAb 2C4 (Pertuzumab, RO4368451) in Japanese Patients with Solid Tumors

OBJECTIVE: rhuMAb 2C4 (pertuzumab, RO4368451), a human epidermal growth factor receptor-2 (HER2) targeted antibody that binds to an epitope distinct from trastuzumab, blocks ligand-associated heterodimerization of HER2 with other HER receptor family members. This study evaluated the toxicity, pharma...

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Detalles Bibliográficos
Autores principales:	Yamamoto, Noboru, Yamada, Yasuhide, Fujiwara, Yutaka, Yamada, Kazuhiko, Fujisaka, Yasuhito, Shimizu, Toshio, Tamura, Tomohide
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661001/ https://www.ncbi.nlm.nih.gov/pubmed/19261664 http://dx.doi.org/10.1093/jjco/hyp006

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