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Successful Versus Failed Adaptation to High-Fat Diet–Induced Insulin Resistance: The Role of IAPP-Induced β-Cell Endoplasmic Reticulum Stress

OBJECTIVE: Obesity is a known risk factor for type 2 diabetes. However, most obese individuals do not develop diabetes because they adapt to insulin resistance by increasing β-cell mass and insulin secretion. Islet pathology in type 2 diabetes is characterized by β-cell loss, islet amyloid derived f...

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Detalles Bibliográficos
Autores principales:	Matveyenko, Aleksey V., Gurlo, Tatyana, Daval, Marie, Butler, Alexandra E., Butler, Peter C.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661593/ https://www.ncbi.nlm.nih.gov/pubmed/19151199 http://dx.doi.org/10.2337/db08-1464

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