Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy

[Image: see text] Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecule...

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Autores principales: Uchida, Takuya, Rodriquez, Manuela, Schreiber, Stuart L.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661762/
https://www.ncbi.nlm.nih.gov/pubmed/19275223
http://dx.doi.org/10.1021/ol900173t
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author Uchida, Takuya
Rodriquez, Manuela
Schreiber, Stuart L.
author_facet Uchida, Takuya
Rodriquez, Manuela
Schreiber, Stuart L.
author_sort Uchida, Takuya
collection PubMed
description [Image: see text] Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future.
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spelling pubmed-26617622009-03-27 Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy Uchida, Takuya Rodriquez, Manuela Schreiber, Stuart L. Org Lett [Image: see text] Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future. American Chemical Society 2009-03-10 2009-04-02 /pmc/articles/PMC2661762/ /pubmed/19275223 http://dx.doi.org/10.1021/ol900173t Text en Copyright © 2009 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org. 40.75
spellingShingle Uchida, Takuya
Rodriquez, Manuela
Schreiber, Stuart L.
Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy
title Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy
title_full Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy
title_fullStr Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy
title_full_unstemmed Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy
title_short Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy
title_sort skeletally diverse small molecules using a build/couple/pair strategy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661762/
https://www.ncbi.nlm.nih.gov/pubmed/19275223
http://dx.doi.org/10.1021/ol900173t
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AT rodriquezmanuela skeletallydiversesmallmoleculesusingabuildcouplepairstrategy
AT schreiberstuartl skeletallydiversesmallmoleculesusingabuildcouplepairstrategy

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