Why are tumour blood vessels abnormal and why is it important to know?

Tumour blood vessels differ from their normal counterparts for reasons that have received little attention. We report here that they are of at least six distinct types, we describe how each forms, and, looking forward, encourage the targeting of tumour vessel subsets that have lost their vascular en...

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Detalles Bibliográficos
Autores principales: Nagy, J A, Chang, S-H, Dvorak, A M, Dvorak, H F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661770/
https://www.ncbi.nlm.nih.gov/pubmed/19240721
http://dx.doi.org/10.1038/sj.bjc.6604929
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author Nagy, J A
Chang, S-H
Dvorak, A M
Dvorak, H F
author_facet Nagy, J A
Chang, S-H
Dvorak, A M
Dvorak, H F
author_sort Nagy, J A
collection PubMed
description Tumour blood vessels differ from their normal counterparts for reasons that have received little attention. We report here that they are of at least six distinct types, we describe how each forms, and, looking forward, encourage the targeting of tumour vessel subsets that have lost their vascular endothelial growth factor-A (VEGF-A) dependency and so are likely unresponsive to anti-VEGF-A therapies.
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spelling pubmed-26617702010-03-24 Why are tumour blood vessels abnormal and why is it important to know? Nagy, J A Chang, S-H Dvorak, A M Dvorak, H F Br J Cancer Minireview Tumour blood vessels differ from their normal counterparts for reasons that have received little attention. We report here that they are of at least six distinct types, we describe how each forms, and, looking forward, encourage the targeting of tumour vessel subsets that have lost their vascular endothelial growth factor-A (VEGF-A) dependency and so are likely unresponsive to anti-VEGF-A therapies. Nature Publishing Group 2009-03-24 2009-02-24 /pmc/articles/PMC2661770/ /pubmed/19240721 http://dx.doi.org/10.1038/sj.bjc.6604929 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Nagy, J A
Chang, S-H
Dvorak, A M
Dvorak, H F
Why are tumour blood vessels abnormal and why is it important to know?
title Why are tumour blood vessels abnormal and why is it important to know?
title_full Why are tumour blood vessels abnormal and why is it important to know?
title_fullStr Why are tumour blood vessels abnormal and why is it important to know?
title_full_unstemmed Why are tumour blood vessels abnormal and why is it important to know?
title_short Why are tumour blood vessels abnormal and why is it important to know?
title_sort why are tumour blood vessels abnormal and why is it important to know?
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661770/
https://www.ncbi.nlm.nih.gov/pubmed/19240721
http://dx.doi.org/10.1038/sj.bjc.6604929
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AT dvorakhf whyaretumourbloodvesselsabnormalandwhyisitimportanttoknow

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